Inovasi Terapi HIV: Menelusuri Potensi Senyawa Alami dan Teknologi Modern
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Abstract
This study aims to review recent developments in HIV drug development through a literature analysis of scientific journals published over the past 10 years. The review findings indicate several innovative approaches that show significant potential in HIV therapy. Flavonoid compounds, such as myricetin and kuwanon-H, exhibit strong antiviral activity against HIV and can be used as natural drug candidates. The use of nanotechnology and carbon nanotube-based delivery systems can enhance drug bioavailability and reduce toxicity. In silico studies have also identified proanthocyanidins as more effective inhibitors of HIV-1 integrase compared to raltegravir, a currently available integrase inhibitor. Furthermore, the development of nanoparticle-based drug delivery systems could enable more targeted drug administration, improving efficiency and reducing side effects. These various innovations have the potential to enhance the effectiveness of HIV therapy in the future, improve the quality of life for patients, and reduce the global burden related to the HIV/AIDS pandemic.
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References
Aisyah, S., & Fitria, A. (2019b). Hubungan pengetahuan dan sikap remaja tentang HIV/AIDS. Jurnal Bidan Komunitas, 2(1), 1.
Dalimoenthe, I. (2011). Perempuan dalam Cengkraman HIV/AIDS. Kajian Sosiologis Feminis Perempuan Ibu Rumah Tangga. Komunitas : Vol 5, No 1, Juli 2011 : 41-48.
Ditjen P2P. (2022). Laporan Eksekutif Perkembangan HIV AIDS dan Penyakit Menular Seksual (PIMS) Triwulan I Tahun 2022. In Kementerian Kesehatan Republik Indonesia. https://hivaids-pimsindonesia.or.id/download/file/LaporanTW_I_2023.pdf
Irwan, I., & Budi, R. (2020). Risiko Penularan HIV/AIDS pada Pekerja Seks Komersial (PSK) di Provinsi Gorontalo.
Kumalasari, I dan Iwan, A. 2012. Kesehatan Reproduksi Untuk Kebidanan Dan Keperawatan. Jakarta: Salemba Medika.
Obeagu, E. ifeanyi, & Obeagu, G. U. (2024). L-selectin dan Traffickign sel imun yang diinduksi HIC : implikasi terhadap patogen dan strategi terapi. Jurnal Elit Kedokeran Laboratorium, 2(2). https://epjournals.com/journals/EJLM
Ortega, J. T., Suárez, A. I., Serrano, M. L., Baptista, J., Pujol, F. H., & Rangel, H. R. (2017). The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro. AIDS Research and Therapy, 14(1). https://doi.org/10.1186/s12981-017-0183-6
Prayogo, B., Widiyanti, P., & Riza, H. (2015). Optimasi Pengaruh Ekstrak Etanol 70 % Bebas dan Tidak Bebas Alkaloid Daun Justicia gendarussa Burm. F terhadap Enzim Reverse Transcriptase HIV in vitro. In Jurnal Kesehatan Khatulistiwa (Vol. 1, Issue 2).
Rosilfa, S., Anazma, M., Laily Hilmi, I., & Sudarjat, H. (2024). Literatur Review: Pengaruh Edukasi Terhadap Pencegahan HIV/AIDS (Vol. 15).
Ruswanto, R., Nofianti, T., Mardianingrum, R., & Lestari, T. (2018). Desain dan Studi In Silico Senyawa Turunan Kuwanon-H sebagai Kandidat Obat Anti-HIV. Jurnal Kimia VALENSI, 4(1), 57–66. https://doi.org/10.15408/jkv.v4i1.6867
Sumakul, V. D. O., Lariwu, C. K., Langingi, A. R. C., Tinggi, S., Kesehatan, I., & Tomohon, G. M. (2023). Pentingnya Pencegahan Penyakit HIV/AIDS Pada Remaja. In Jurnal Pengabdian kepada Masyarakat MAPALUS Sekolah Tinggi Ilmu Kesehatan Gunung Maria Tomohon (Vol. 1, Issue 2).
Srivastava, N., Mishra, V., Mishra, Y., Ranjan, A., Aljabali, A. A. A., El-Tanani, M., Alfagih, I. M., & Tambuwala, M. M. (2024). Development and evaluation of a protease inhibitor antiretroviral drug-loaded carbon nanotube delivery system for enhanced efficacy in HIV treatment. International Journal of Pharmaceutics, 650. https://doi.org/10.1016/j.ijpharm.2023.123678
Tamim, G. A., Arumsari, A., & Miftah, A. M. (2020). Uji Senyawa Proantosianidin Daun Matoa terhadap Reseptor Hiv-1 Integrase Secara In Silico. Prosiding Farmasi, 6(2). https://doi.org/10.29313/.v6i2.23027
Trickey et.all.,(2017). Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies. The Lancet HIV, 4(8), e349–e356. https://doi.org/10.1016/S2352-3018(17)30066-8
Wijaya, S., & Arifin, M. (2018). Analisis Potensi Nanocurcumin Terkapsulasi Apotransferrin Sebagai Inovasi Pengembangan Terapi Pada Penderita HIV/AIDS.
Woradulayapinij, W., Soonthornchareonnon, N., & Wiwat, C. (2022). In vitro HIV type 1 reverse transcriptase inhibitory activities of Thai medicinal plants and Canna indica L. rhizomes. Journal of Ethnopharmacology, 101(1–3), 84–89. https://doi.org/10.1016/j.jep.2005.03.030
Yuliyanasari, N. (2017). Global Burden Desease-Human Immunodeficiency Virus-Acquired Immune Deficiency Syndrome (HIV-AIDS).